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Important information

Conduction disturbance rarely with hemodynamic compromise has been observed when Coreg is coadministered with diltiazem. As with other agents with β-blocking properties, if Coreg is to be administered with calcium channel blockers of the verapamil or diltiazem type, it is recommended that ECG and blood pressure be monitored. Doxepin hydrochloride is one of a class of psychotherapeutic agents known as dibenzoxepin tricyclic compounds. Other brands of medicine that contain the same ingredient fluoxetine are available. These other brands may be used to treat depression or other mental problems. Do not take Sarafem if you are taking any other medicine that contains fluoxetine. Discuss any questions or concerns with your doctor. generic doxazosin usage doxazosin

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If you notice any of these symptoms in your especially during their first month, tell the doctor right away. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure. Fluoxetine and norFluoxetine concentrations were observed in children relative to adults; however, these concentrations were within the range of concentrations observed in the adult population.

List of fluoxetine side effects

Sedating drugs may cause confusion and over sedation in the elderly; elderly patients generally should be started on low doses of Doxepin and observed closely. See WARNINGS. Coreg has been evaluated for safety in subjects with heart failure mild, moderate, and severe in subjects with left ventricular dysfunction following myocardial infarction and in hypertensive subjects The observed adverse event profile was consistent with the pharmacology of the drug and the health status of the subjects in the clinical trials. Adverse events reported for each of these patient populations are provided below. Excluded are adverse events considered too general to be informative, and those not reasonably associated with the use of the drug because they were associated with the condition being treated or are very common in the treated population. Rates of adverse events were generally similar across demographic subsets men and women, elderly and non-elderly, blacks and non-blacks.

Fluoxetine uses

What are the possible side effects of SARAFEM? Concomitant ingestion of alcohol is not advised. Monoamine Oxidase Inhibitor MAOI. Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid. Fluoxetine has not been systematically studied, in animals or humans, for its potential for abuse, tolerance, or physical dependence.



Use of fluoxetine

Other side effects of Coreg include shortness of breath, weight gain, diarrhea, and fewer tears or dry eyes that become bothersome if you wear contact lenses. Certain antidepressants, including Sarafem, may increase the risk of bleeding. Sometimes, bleeding can be life-threatening. Discuss any questions or concerns with your doctor. Diagnostic and Statistical Manual-4th edition criteria for PMDD. IV category of Major Depressive Disorder. Cigarette may decrease levels of this medication. You may need to stop taking this drug beforehand. Follow your doctor's instructions carefully. These are not all the possible side effects of SARAFEM. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Learn all preparation and usage instructions in the product package. If any of the information is unclear, consult your doctor or pharmacist. This dose may be given at bedtime. Anti-anxiety effect is apparent before the antidepressant effect. Optimal antidepressant effect may not be evident for two to three weeks. Cardiovascular: Cardiovascular effects including hypotension, hypertension, and tachycardia have been reported occasionally. If the pH response is inadequate, hyperventilation may also be used. Concomitant use of hyperventilation and sodium bicarbonate should be done with extreme caution, with frequent pH monitoring. Continued How Is ECT Performed? This may not be a complete list of all interactions that may occur. Ask your health care provider if fluoxetine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. You should feel some relief within 30 minutes. Tell your doctor if your condition persists or worsens.



Fluoxetine overdose

Coreg is a registered trademark of the GSK group of companies. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Doxepin Hydrochloride Oral Solution USP Concentrate is available in 120 mL bottles NDC 54838-512-40 with an accompanying dropper calibrated at 5 mg, 10 mg, 15 mg, 20 mg, and 25 mg. Each mL contains Doxepin hydrochloride equivalent to 10 mg Doxepin. Immediately prior to taking this medication, dilute each dose with approximately 120 mL 4 ounces of water, whole or skimmed milk, or orange, grapefruit, tomato, prune or pineapple juice. Doxepin Hydrochloride Oral Solution USP Concentrate is not physically compatible with a number of carbonated beverages. Fluoxetine has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. In patients of all ages who are started on antidepressant therapy, monitor closely for worsening and for emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber. Fluoxetine with single doses of terfenadine a CYP3A4 substrate no increase in plasma terfenadine concentrations occurred with concomitant Fluoxetine. Changes in dose will not be fully reflected in plasma for several weeks due to the long elimination half-lives of fluoxetine and its major active metabolite. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. SNRIs and SSRIs, including Fluoxetine, may increase the risk of bleeding reactions. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, warfarin, and other anti-coagulants may add to this risk. Case reports and epidemiological studies case-control and cohort design have demonstrated an association between use of drugs that interfere with serotonin reuptake and the occurrence of gastrointestinal bleeding. Bleeding reactions related to SNRIs and SSRIs use have ranged from ecchymoses, hematomas, epistaxis, and petechiae to life-threatening hemorrhages. What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions? Dosage: See accompanying prescribing information. Its molecular weight is 345. If you miss a dose of fluoxetine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Abrupt withdrawal of β-blockade may be followed by an exacerbation of the symptoms of hyperthyroidism or may precipitate thyroid storm. lexapro



What other drugs will affect fluoxetine

It is not known if Coreg passes into your breast milk. You should not breastfeed while using Coreg. Central Nervous System Effects: Drowsiness is the most commonly noticed side effect. This tends to disappear as therapy is continued. Other infrequently reported CNS side effects are confusion, disorientation, hallucinations, numbness, paresthesias, ataxia, extrapyramidal symptoms, seizures, tardive dyskinesia, and tremor. Inactive Ingredients: colloidal silicon dioxide, crospovidone, hypromellose, lactose, magnesium stearate, polyethylene glycol, polysorbate 80, povidone, sucrose, and titanium dioxide. Store fluoxetine at room temperature, between 59 and 86 degrees F 15 and 30 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep fluoxetine out of the reach of children and away from pets. Fluoxetine hydrochloride, USP is a white to off-white crystalline powder, it is freely soluble in alcohol and in methanol, sparingly soluble in water and in dichloromethane, practically insoluble in ether. Do not stop taking Coreg and do not change the amount of Coreg you take without talking to your doctor. Consider ECG assessment and periodic ECG monitoring if initiating treatment with Fluoxetine in patients with risk factors for QT prolongation and ventricular arrhythmia. Consider discontinuing Fluoxetine and obtaining a cardiac evaluation if patients develop signs or symptoms consistent with ventricular arrhythmia. When treating a pregnant woman with Fluoxetine, the physician should carefully consider both the potential risks of taking an SSRI, along with the established benefits of treating depression with an antidepressant. Bulimia treatment requires the consideration of the physical as well as the psychological needs of the person. In clinical trials of subjects with heart failure, subjects with bronchospastic disease were enrolled if they did not require oral or inhaled medication to treat their bronchospastic disease. In such patients, it is recommended that carvedilol be used with caution. The dosing recommendations should be followed closely and the dose should be lowered if any evidence of bronchospasm is observed during up-titration. Body as a Whole: Allergy, malaise, hypovolemia, fever, leg edema. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; black or bloody stools; chest pain; confusion; decreased concentration; decreased coordination; decreased sexual desire or ability; exaggerated reflexes; excessive sweating; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; joint or wrist aches or pain; memory problems; new or worsening mental, mood, or behavior changes eg, depression, anxiety, agitation, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, or inability to sit still; persistent or severe ringing in the ears; persistent trouble sleeping; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness or headache; severe or persistent nausea, vomiting, diarrhea, or stomach pain; significant weight loss; suicidal thoughts or attempts; tremor; trouble urinating; unusual bruising or bleeding; unusual weakness; vomit that looks like coffee grounds. Major Depressive Disorder, 11% of patients treated with Fluoxetine and 2% of patients treated with placebo reported anorexia decreased appetite.



Prescribing information for fluoxetine

Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. There has been a long standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Pooled analyses of short-term placebo-controlled trials of antidepressant drugs SSRIs and others showed that these drugs increase the risk of suicidal thinking and behavior suicidality in children, adolescents, and young adults ages 18-24 with major depressive disorder MDD and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction with antidepressants compared to placebo in adults aged 65 and older. The following adverse reactions have been identified during post-approval use of Coreg. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Significant weight loss, especially in underweight depressed or bulimic patients, may be an undesirable result of treatment with Fluoxetine. Older adults may also be more likely to develop in the blood, especially if they are taking "water pills" diuretics. Drowsiness, confusion, and dizziness can increase the risk of falling. Coreg. These reactions can be life-threatening. Autonomic Nervous System: Dry mouth, sweating increased. Inactive ingredients consist of colloidal silicon dioxide, crospovidone, hypromellose, lactose, magnesium stearate, polyethylene glycol, polysorbate 80, povidone, sucrose, and titanium dioxide. If you miss a dose of Sarafem, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not suddenly stop taking Sarafem without checking with your doctor. Side effects may occur. They may include mental or mood changes, numbness or tingling of the skin, dizziness, confusion, headache, trouble sleeping, or unusual tiredness. You will be closely monitored when you start Sarafem and whenever a change in dose is made. The developing trial data were followed by a data monitoring committee, and mortality analyses were adjusted for these multiple looks. Patients on stable doses of phenytoin and carbamazepine have developed elevated plasma anticonvulsant concentrations and clinical anticonvulsant toxicity following initiation of concomitant Fluoxetine treatment. Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms. Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. The magnitude of the impact of this factor is small in comparison to the overall variability between individuals, and therefore dose modification is not routinely recommended. store flonase interaction



Fluoxetine ingredients

Changes in appetite or weight. Children and adolescents should have height and weight monitored during treatment. How should I take Coreg? Although carvedilol is metabolized primarily by the liver, plasma concentrations of carvedilol have been reported to be increased in patients with renal impairment. Based on mean AUC data, approximately 40% to 50% higher plasma concentrations of carvedilol were observed in hypertensive subjects with moderate to severe renal impairment compared with a control group of hypertensive subjects with normal renal function. However, the ranges of AUC values were similar for both groups. Changes in mean peak plasma levels were less pronounced, approximately 12% to 26% higher in subjects with impaired renal function. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. When using Fluoxetine and olanzapine in combination, also refer to the Warnings and Precautions section of the package insert for Symbyax. There have been spontaneous reports in women taking Fluoxetine of orgasmic dysfunction, including anorgasmia.



Consult your doctor before -feeding

MAO Inhibitors: Serious side effects and even death have been reported following the concomitant use of certain drugs with MAO inhibitors. Therefore, MAO inhibitors should be discontinued at least two weeks prior to the cautious initiation of therapy with Doxepin. The exact length of time may vary and is dependent upon the particular MAO inhibitor being used, the length of time it has been administered, and the dosage involved. If you miss a dose, do not worry. Ask if you are not sure. It is not known whether this drug is excreted in human milk. PREGNANCY and BREAST-FEEDING: Fluoxetine may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using fluoxetine while you are pregnant. Fluoxetine is found in breast milk. Do not breast-feed while you are taking fluoxetine. differin purchase online shopping usa



How to use fluoxetine

If you miss a dose, take as soon as you remember unless the next scheduled dose is within 2 hours. In that case, skip the missed dose and resume your usual dosing schedule. Endocrine: Raised or lowered libido, testicular swelling, gynecomastia in males, enlargement of breasts and galactorrhea in the female, raising or lowering of blood sugar levels, and syndrome of inappropriate antidiuretic hormone secretion have been reported with tricyclic administration. When using Fluoxetine and olanzapine in combination, also refer to Boxed Warning section of the package insert for Symbyax. This call is free. How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member? Usage in Pregnancy: Reproduction studies have been performed in rats, rabbits, monkeys and dogs and there was no evidence of harm to the animal fetus. The relevance to humans is not known. Since there is no experience in pregnant women who have received this drug, safety in pregnancy has not been established. There has been a report of apnea and drowsiness occurring in a nursing infant whose mother was taking Doxepin. PMDD does not exist in pregnancy. Fluoxetine Tablets affect you. Do not drink alcohol while using Fluoxetine Tablets. Anaphylactoid reactions, including bronchospasm, angioedema, laryngospasm, and urticaria alone and in combination, have been reported. Subjects treated with carvedilol showed significant improvements in global assessments compared with those treated with placebo in COPERNICUS. SARAFEM may impair judgment, thinking, or motor skills. Avoid strenuous while taking this medication. IV heart failure receiving diuretics, ACE inhibitors, and digitalis. There were significant reductions in systemic blood pressure, pulmonary artery pressure, pulmonary capillary wedge pressure, and heart rate. Initial effects on cardiac output, stroke volume index, and systemic vascular resistance were small and variable.



About fluoxetine

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Patients with concurrent disease or those on multiple concomitant medicines may require dose adjustment. Read the Guide provided by your before you start using and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Major Depressive Disorder as well as for other indications, both psychiatric and nonpsychiatric. Older adults may be more sensitive to the side effects of this drug, especially bleeding and QT prolongation see above. Older adults may also be more likely to develop in the blood, especially if they are taking "water pills" diuretics. Included as part of the PRECAUTIONS section. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Doxepin Hydrochloride Oral Solution and should counsel them in its appropriate use. A patient Medication Guide about “Antidepressant Medicines, Depression and other Serious Mental Illness, and Suicidal Thoughts or Actions” is available for Doxepin Hydrochloride Oral Solution. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document. When using Fluoxetine and olanzapine and in combination, also refer to the Drug Interactions section of the package insert for Symbyax. Abnormal dreams; anxiety; diarrhea; dizziness; drowsiness; dry mouth; flu-like symptoms eg, fever, chills, muscle aches; flushing; increased sweating; loss of appetite; nausea; nervousness; runny or stuffy nose; sore throat; stomach upset; trouble sleeping; weakness; yawning. Fluoxetine was discontinued. Elderly patients may be at greater risk of developing hyponatremia with SNRIs and SSRIs. Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug. Furthermore, whenever one of these other drugs is withdrawn from co-therapy, an increased dose of tricyclic antidepressant may be required. It is desirable to monitor TCA plasma levels whenever a TCA is going to be coadministered with another drug known to be an inhibitor of P450 2D6. This is a combination of 2 drugs, an antipsychotic drug and a selective serotonin reuptake inhibitor-SSRI. Coreg is rapidly and extensively absorbed following oral administration, with absolute bioavailability of approximately 25% to 35% due to a significant degree of first-pass metabolism. Bronchial asthma or related bronchospastic conditions. Deaths from status asthmaticus have been reported following single doses of Coreg. Psychiatric: Nervousness, sleep disorder, aggravated depression, impaired concentration, abnormal thinking, paroniria, emotional lability. tenormin



Fluoxetine adult dosage

Patients should be advised that taking Doxepin Hydrochloride Oral Solution can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle- closure glaucoma. Pre-existing glaucoma is almost always open-angle glaucoma because angle- closure glaucoma, when diagnosed, can be treated definitively with iridectomy. Open-angle glaucoma is not a risk factor for angle closure glaucoma. Infrequent: dysphagia, gastritis, gastroenteritis, melena, stomach ulcer; Rare: bloody diarrhea, duodenal ulcer, esophageal ulcer, gastrointestinal hemorrhage, hematemesis, hepatitis, peptic ulcer, stomach ulcer hemorrhage. Medicines that are sometimes used to treat behaviors related to include selective serotonin reuptake inhibitors SSRIs and antipsychotic medicines. National Library of Medicine and Drugs. Antidepressants increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect or predict the rates observed in practice. The mechanism of action of Doxepin hydrochloride is not definitely known. It is not a central nervous system stimulant nor a monoamine oxidase inhibitor. The current hypothesis is that the clinical effects are due, at least in part, to influences on the adrenergic activity at the synapses so that deactivation of norepinephrine by reuptake into the nerve terminals is prevented. Animal studies suggest that Doxepin hydrochloride does not appreciably antagonize the antihypertensive action of guanethidine. In animal studies anticholinergic, antiserotonin and antihistamine effects on smooth muscle have been demonstrated. At higher than usual clinical doses, norepinephrine response was potentiated in animals. This effect was not demonstrated in humans. The patient should be placed in a supine position and, where necessary, kept under observation and treated under intensive-care conditions. Take Coreg with food. Changes in the electrical activity of your heart QT prolongation and ventricular arrhythmia including Torsades de Pointes. This condition can be life threatening.



How to take fluoxetine

This comes in individual nasal spray vials. Each vial contains enough medication to treat a single attack. not use more than 4 sprays for a single attack. Before using each nasal spray vial, prime the pump by spraying 4 times into the air, away from the face. Store below 30 oC 86 oF. This medication may be taken with or without food. Dosage is based on your medical condition and response to therapy. Coreg has not been associated with clinically significant changes in serum potassium, total triglycerides, total cholesterol, HDL cholesterol, uric acid, blood urea nitrogen, or creatinine. No clinically relevant changes were noted in fasting serum glucose in hypertensive patients; fasting serum glucose was not evaluated in the heart failure clinical trials. This is used to treat attacks. It helps relieve pain and other symptoms such as sensitivity to light or sound. The total daily dosage of Doxepin may be given on a divided or once-a-day dosage schedule. Brand Names: Prozac, Sarafem, Prozac Weekly, Selfemra Generic Name: Fluoxetine Drug Class: Antidepressants, SSRIs What Is Fluoxetine and How Does It Work? Activated charcoal should be administered. Due to the large volume of distribution of this drug, forced diuresis, dialysis, hemoperfusion, and exchange transfusion are unlikely to be of benefit. No specific antidotes for Fluoxetine are known. topiramate shop in melbourne



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Fluoxetine or placebo in the morning

Renal impairment: Use caution; drug accumulation may occur with severe renal impairment. Patients should be advised of the following issues and asked to alert their healthcare provider if these occur while taking Fluoxetine. SARAFEM will harm your unborn baby. The size of the effect was related to baseline frequency, with greater reductions seen in patients with higher baseline frequencies. patum.info asacol

Fluoxetine side effects

Worsening of severe allergic reactions. Families and caregivers of patients being treated with antidepressants for Major Depressive Disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of agitation, irritability, unusual changes in behavior, and the other symptoms described above, as well as the emergence of suicidality, and to report such symptoms immediately to health care providers. Such monitoring should include daily observation by families and caregivers. What should I tell my doctor before taking Coreg?

Do not -feed while using this drug

Patients should be advised to consult with their healthcare provider if their symptoms do not improve with Fluoxetine. In general, alternative therapies by themselves are reasonable to use for mild but not more severe forms of clinical depression. Additional dose increases may be considered after several more weeks if insufficient clinical improvement is observed. It may harm an unborn baby. If you become or think you may be pregnant, tell your doctor right away. All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases.

Fluoxetine dosage

Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Anyone considering the use of Doxepin hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Doxepin Hydrochloride Oral Solution is not approved for use in pediatric patients. See Warnings: Clinical Worsening and Suicide Risk, Precautions: Information for Patients, and Precautions: Pediatric Use.

Bulimia is a condition that is difficult to cure. Many people improve, but relapses may recur from time to time in some cases. In addition, some people who are considered "cured" continue with less-than-normal eating patterns throughout their lives. Patients should be advised that initiation of treatment and to a lesser extent dosage increases may be associated with transient symptoms of dizziness or lightheadedness and rarely syncope within the first hour after dosing. During these periods, patients should avoid situations such as driving or hazardous tasks, where symptoms could result in injury. Vasodilatory symptoms often do not require treatment, but it may be useful to separate the time of dosing of Coreg from that of the ACE inhibitor or to reduce temporarily the dose of the ACE inhibitor. The dose of Coreg should not be increased until symptoms of worsening heart failure or vasodilation have been stabilized.

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